Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis
نویسندگان
چکیده
منابع مشابه
Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood stem cell transplantation.
Hematopoietic reconstitution after stem cell transplantation requires excessive replicative activity because of the limited number of stem cells that are used for transplantation. Telomere shortening has been detected in hematopoietic cells after bone marrow transplantation. This has been thought to result from excessive replication of the stem cells, with putative concomitant reduction of thei...
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Telomeres are repetitive sequence structures at the ends of linear chromosomes that consist of double-stranded DNA repeats followed by a short single-stranded DNA protrusion. Telomeres need to be replicated in each cell cycle and protected from DNA-processing enzymes, tasks that cells execute using specialized protein complexes such as telomerase (that includes TERT), which aids in telomere mai...
متن کاملIdentification of Human Rap1 Implications for Telomere Evolution
It has been puzzling that mammalian telomeric proteins, including TRF1, TRF2, tankyrase, and TIN2 have no recognized orthologs in budding yeast. Here, we describe a human protein, hRap1, that is an ortholog of the yeast telomeric protein, scRap1p. hRap1 has three conserved sequence motifs in common with scRap1, is located at telomeres, and affects telomere length. However, while scRap1 binds te...
متن کاملTelomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, reactive oxygen species, and genome instability. However, the contribution of telomere-associated versus telomere-independent endogenous DNA lesions to this damage has never been examined. In this study, we characterized the relative amounts...
متن کاملTelomere biology of human hematopoietic stem cells.
BACKGROUND Telomeres are protein DNA structures present at the ends of chromosomes and are essential for genetic stability and cell replication. Telomerase is the enzyme complex that maintains telomere integrity. Hematopoietic stem cells express telomerase and contain long telomeres, which become shorter as cells differentiate and mature. The extent of telomere shortening and the level of telom...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2019
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-019-0610-7